proteasome inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T9710	Dazcapistat		Cysteine Protease
	Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.		Cysteine Protease
T6432	Calpeptin		Apoptosis , Cysteine Protease , Proteasome
	Calpeptin is a potent, cell-permeable calpain inhibitor.		Apoptosis , Cysteine Protease , Proteasome
T9090	MUN57694		Proteasome
	MUN57694 is an inhibitor of 26S proteasome.		Proteasome
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T13858	RA190		Proteasome
	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.		Proteasome
T2470	MDL-28170	Calpain Inhibitor III	Cysteine Protease , Proteasome
	MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.		Cysteine Protease , Proteasome
T3786	Tomatine	lycopersicin	Apoptosis , Proteasome
	Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.		Apoptosis , Proteasome
T7814	Alloxan monohydrate		Proteasome
	Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.		Proteasome
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T1795	Carfilzomib	PR-171	Apoptosis , Proteasome , Autophagy
	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma.		Apoptosis , Proteasome , Autophagy
T3695	Pepstatin	Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives , Proteasome , HIV Protease , Autophagy
	Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T9809	E3 ligase Ligand 23		Ligand for E3 Ligase
	E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.		Ligand for E3 Ligase
T8397	Ixazomib citrate	MLN9708	Proteasome , Autophagy
	Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.		Proteasome , Autophagy
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome